Brendan Anthony O'Brien (born 2 September 1942) is a former Irish cricketer. O'Brien was a right-handed batsman. He was born at Galway in 1942.
| Format | Matches | Runs | Avg | 100s/50s | Top Score | Catches/St |
| First-class | 11 | 319 | 19.93 | 0/0 | 45* | 6/– |
| List A | 2 | 2 | 1.00 | 0/0 | 1 | 1/– |
